Endocrine Abstracts

Introduction: Recently, vitamin D3 (cholecalciferol) deficiency has been considered as one of the factors for the development of type 2 diabetes mellitus (T2D) and metabolic syndrome (MS), which contributes to increased insulin resistance (IR) and reduced insulin secretion. The most pronounced vitamin D deficiency is observed in persons suffering from morbid obesity. The aim of this study was to assess IR, b-cell functional activity and metabolic profile parameters according t...

Background: Probiotics have beneficial effect on obesity, insulin resistance and associated metabolic disorders. However, effect of probiotics on β-cell function are inconsistent.Aim: In a double-blind single center randomized placebo-controlled trials (RCT), effect of alive multistrain probiotic vs. placebo on β-cell function in type 2 diabetes patient were assessed.Methods: A total of 54 patients met the criteria for in...

Background: Recently, vitamin D3 deficiency is considered one of the factors associated with the development of non-alcoholic fatty liver disease (NAFLD). The aim was to evaluate steatosis indices and metabolic parameters in NAFLD depending on D3 status.Materials and methods: According to the recommendations of the European Society of Endocrinology, all patients were divided into 3 groups: group 1 – with an optimal level of vitamin D3 (30 ng/m...

Background: Probiotics and omega-3 polyunsaturated fatty acids supplementation (PUFA) have beneficial effect on obesity related disorders in animal models. We have previously shown, on rats with monosodium glutamate-induced obesity, that in take of the combination based on live probiotics and omega-3 PUFA is accompanied by the preventive effect concerning experimental obesity development, lead toinsulin resistance (IR) improvement and more obvious decrease of he paticsteatosis...